Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis

被引：255

作者：

Kryczek, Ilona

Wei, Shuang

Keller, Evan

Liu, Rebecca

Zou, Weiping

机构：

[1] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2007年 / 292卷 / 03期

关键词：

migration; immune suppression; tumor angiogenesis; tumor metastasis; stem cells;

D O I：

10.1152/ajpcell.00406.2006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chemokine stroma-derived factor (SDF-1/CXCL12) plays multiple roles in tumor pathogenesis. It has been demonstrated that CXCL12 promotes tumor growth and malignancy, enhances tumor angiogenesis, participates in tumor metastasis, and contributes to immunosuppressive networks within the tumor microenvironment. Therefore, it stands to reason that the CXCL12/CXCR4 pathway is an important target for the development of novel anti-cancer therapies. In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed.

引用

页码：C987 / C995

页数：9

共 159 条

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