Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells: an additional mechanism to subendothelium oxidation

被引：55

作者：

Boudjeltia, KZ ^{[1
]}

Moguilevsky, N

Legssyer, I

Babar, S

Guillaume, M

Delree, P

Vanhaeverbeek, M

Brohee, D

Ducobu, J

Remacle, C

机构：

[1] Hop Vesale, Lab Med Expt, ULB 222 Unit, Montignies le Tilleul, Belgium

[2] Univ Calif Los Angeles, Lab Biol Cellulaire, Louvain, Belgium

[3] Inst Pathol & Genet, Loverval, Belgium

[4] Free Univ Brussels, IBMM, Serv Genet, Gosselies, Belgium

[5] CHU Tivoli, Serv Med Interne, La Louviere, Belgium

[6] Univ Namur, Technol Transfer Off, Namur, Belgium

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 325卷 / 02期

关键词：

myeloperoxidase; LDL; endothelial cells; Mox-LDL;

D O I：

10.1016/j.bbrc.2004.10.049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present paradigm of atherogenesis proposes that low density lipoproteins (LDL) are trapped in subendothelial space of the vascular wall where they are oxidized. Myeloperoxidase (MPO) plays a key role in oxidative damage. We propose that LDL oxidation by myeloperoxidase (Mox-LDL) could occur at the surface of the endothelial cells and not restricted to the subendothelial space. The triad constituted by endothelial cells, circulating LDL and MPO in close interaction, constitutes a synergic mechanism for the genesis of Mox-LDL. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：434 / 438

页数：5

共 26 条

[1] Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes [J].

Baldus, S ;

Heeschen, C ;

Meinertz, T ;

Zeiher, AM ;

Eiserich, JP ;

Münzel, T ;

Simoons, ML ;

Hamm, CW .

CIRCULATION, 2003, 108 (12) :1440-1445

[2] Prognostic value of myeloperoxidase in patients with chest pain [J].

Brennan, M ;

Penn, MS ;

Van Lente, F ;

Nambi, V ;

Shishehbor, MH ;

Aviles, RJ ;

Goormastic, M ;

Pepoy, ML ;

McErlean, ES ;

Topol, EJ ;

Nissen, SE ;

Hazen, SL .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (17) :1595-1604

[3] Human apo-lipoprotein B from normal plasma contains oxidised peptides [J].

Bruce, D ;

Fu, SL ;

Armstrong, S ;

Dean, RT .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1999, 31 (12) :1409-1420

[4] Widespread coronary inflammation in unstable angina [J].

Buffon, A ;

Biasucci, LM ;

Liuzzo, G ;

D'Onofrio, G ;

Crea, F ;

Maseri, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (01) :5-12

[5] Myeloperoxidase binds to low-density lipoprotein: potential implications for atherosclerosis [J].

Carr, AC ;

Myzak, MC ;

Stocker, R ;

McCall, MR ;

Frei, B .

FEBS LETTERS, 2000, 487 (02) :176-180

[6] Association of myeloperoxidase with heparin: Oxidative inactivation of proteins on the surface of endothelial cells by the bound enzyme [J].

Daphna, EM ;

Michaela, S ;

Eynat, P ;

Irit, A ;

Rimon, S .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1998, 183 (1-2) :55-61

[7] MYELOPEROXIDASE, A CATALYST FOR LIPOPROTEIN OXIDATION, IS EXPRESSED IN HUMAN ATHEROSCLEROTIC LESIONS [J].

DAUGHERTY, A ;

DUNN, JL ;

RATERI, DL ;

HEINECKE, JW .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :437-444

[8] Presence of hypochlorite-modified proteins in human atherosclerotic lesions [J].

Hazell, LJ ;

Arnold, L ;

Flowers, D ;

Waeg, G ;

Malle, E ;

Stocker, R .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (06) :1535-1544

[9]

Heinecke JW, 2003, AM J CARDIOL, V91, p12A

[10]

Holland JA, 1996, J CELL PHYSIOL, V166, P144, DOI 10.1002/(SICI)1097-4652(199601)166:1<144::AID-JCP17>3.0.CO

← 1 2 3 →