Human Medial Orbitofrontal Cortex Is Recruited During Experience of Imagined and Real Rewards

被引：75

作者：

Bray, Signe ^{[1
]}

Shimojo, Shinsuke ^{[1
,2
]}

O'Doherty, John P. ^{[2
,3
,4
]}

机构：

[1] Stanford Univ, Ctr Interdisciplinary Brain Sci Res, Palo Alto, CA 94305 USA

[2] CALTECH, Div Biol, Pasadena, CA 91125 USA

[3] Trinity Coll Dublin, Inst Neurosci, Dublin, Ireland

[4] Trinity Coll Dublin, Sch Psychol, Dublin, Ireland

来源：

JOURNAL OF NEUROPHYSIOLOGY | 2010年 / 103卷 / 05期

基金：

美国国家科学基金会;

关键词：

EVENT-RELATED FMRI; PREDICTION ERRORS; HUMAN BRAIN; PREFRONTAL CORTEX; EPISODIC MEMORY; DECISION-MAKING; DORSAL STRIATUM; REPRESENTATIONS; FACES; PLEASANTNESS;

D O I：

10.1152/jn.01030.2009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bray S, Shimojo S, O'Doherty JP. Human medial orbitofrontal cortex is recruited during experience of imagined and real rewards. J Neurophysiol 103: 2506-2512, 2010. First published March 3, 2010; doi: 10.1152/jn.01030.2009. Human decision-making frequently relies on mental simulation of future rewards to guide action choice. In this study, we sought to uncover brain regions engaged during reward imagery and to address whether these regions functionally overlap with regions activated by tangible rewards. We found that medial orbitofrontal cortex (mOFC) is engaged both for real and imagined rewards and is preferentially engaged for imagery with rewarding content compared with other nonrewarding imagery. These findings support a critical role for mOFC in the representation of rewarding goal states, even if hypothetical.

引用

页码：2506 / 2512

页数：7

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