Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling

被引：188

作者：

Zeitlinger, J ^{[1
]}

Simon, I ^{[1
]}

Harbison, CT ^{[1
]}

Hannett, NM ^{[1
]}

Volkert, TL ^{[1
]}

Fink, GR ^{[1
]}

Young, RA ^{[1
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

CELL | 2003年 / 113卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(03)00301-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Specialized gene expression programs are induced by signaling pathways that act on transcription factors. Whether these transcription factors can function in multiple developmental programs through a global switch in promoter selection is not known. We have used genome-wide location analysis to show that the yeast Ste12 transcription factor, which regulates mating and filamentous growth, is bound to distinct program-specific target genes dependent on the developmental condition. This condition-dependent distribution of Ste12 requires concurrent binding of the transcription factor Tec1 during filamentation and is differentially regulated by the MAP kinases Fus3 and Kss1. Program-specific distribution across the genome may be a general mechanism by which transcription factors regulate distinct gene expression programs in response to signaling.

引用

页码：395 / 404

页数：10

共 59 条

[1] THE ASPERGILLUS-NIDULANS ABAA GENE ENCODES A TRANSCRIPTIONAL ACTIVATOR THAT ACTS AS A GENETIC SWITCH TO CONTROL DEVELOPMENT [J].