The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses

被引：119

作者：

Yost, Christian C. ^{[1
,2
]}

Weyrich, Andrew S. ^{[1
,3
]}

Zimmerman, Guy A. ^{[1
,3
]}

机构：

[1] Univ Utah, Eccles Inst Human Genet, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Pediat, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA

来源：

BIOCHIMIE | 2010年 / 92卷 / 06期

关键词：

Platelet-activating factor; Sepsis; Anaphylaxis; Inflammation; Lipid mediators; FACTOR RECEPTOR ANTAGONIST; RESPIRATORY-DISTRESS-SYNDROME; MULTIPLE ORGAN FAILURE; ACUTE LUNG INJURY; PHASE-II TRIAL; NF-KAPPA-B; FACTOR-ACETYLHYDROLASE; SEVERE SEPSIS; DOUBLE-BLIND; CLINICAL-TRIAL;

D O I：

10.1016/j.biochi.2010.02.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The platelet-activating factor (PAF) signaling cascade evolved as a component of the repertoire of innate host defenses, but is also an effector pathway in inflammatory and thrombotic diseases. This review focuses on the PAF signaling cascade in systemic inflammatory responses and, specifically, explores its activities in experimental and clinical sepsis and anaphylaxis in the context of the basic biochemistry and biology of signaling via this lipid mediator system. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：692 / 697

页数：6

共 80 条

[1] Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells [J].

Al-Darmaki, S ;

Schenkein, HA ;

Tew, JG ;

Barbour, SE .

JOURNAL OF IMMUNOLOGY, 2003, 170 (01) :167-173

[2] Systemic inflammatory response and progression to severe sepsis in critically ill infected patients [J].

Alberti, C ;

Brun-Buisson, C ;

Chevret, S ;

Antonelli, M ;

Goodman, SV ;

Martin, C ;

Moreno, R ;

Ochagavia, AR ;

Palazzo, M ;

Werdan, K ;

Le Gall, JR .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (05) :461-468

[3] Platelet-activating factor acetylhydrolase (PAF-AH) [J].

Arai, H ;

Koizumi, H ;

Aoki, J ;

Inoue, K .

JOURNAL OF BIOCHEMISTRY, 2002, 131 (05) :635-640

[4] Pathobiology of sepsis - Are we still asking the same questions? [J].

Baron, RM ;

Baron, MJ ;

Perrella, MA .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2006, 34 (02) :129-134

[5] Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats [J].

Belanger, Caroline ;

Elimam, Hanan ;

Lefebvre, Julie ;

Borgeat, Pierre ;

Marleau, Sylvie .

IMMUNOLOGY, 2008, 124 (03) :295-303

[6] Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice [J].

Camerer, Eric ;

Regard, Jean B. ;

Cornelissen, Ivo ;

Srinivasan, Yoga ;

Duong, Daniel N. ;

Palmer, Daniel ;

Pham, Trung H. ;

Wong, Jinny S. ;

Pappu, Rajita ;

Coughlin, Shaun R. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (07) :1871-1879

[7]

Caplan Michael S, 2005, Semin Pediatr Surg, V14, P145, DOI 10.1053/j.sempedsurg.2005.05.002

[8] ROLE OF PLATELET ACTIVATING FACTOR AND TUMOR NECROSIS FACTOR-ALPHA IN NEONATAL NECROTIZING ENTEROCOLITIS [J].

CAPLAN, MS ;

SUN, XM ;

HSUEH, W ;

HAGEMAN, JR .

JOURNAL OF PEDIATRICS, 1990, 116 (06) :960-964

[9] Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood [J].

Clark, Stephen R. ;

Ma, Adrienne C. ;

Tavener, Samantha A. ;

McDonald, Braedon ;

Goodarzi, Zahra ;

Kelly, Margaret M. ;

Patel, Kamala D. ;

Chakrabarti, Subhadeep ;

McAvoy, Erin ;

Sinclair, Gary D. ;

Keys, Elizabeth M. ;

Allen-Vercoe, Emma ;

DeVinney, Rebekah ;

Doig, Christopher J. ;

Green, Francis H. Y. ;

Kubes, Paul .

NATURE MEDICINE, 2007, 13 (04) :463-469

[10] Plasma platelet-activating factor acetylhydrolase activity in critically ill patients [J].

Claus, RA ;

Russwurm, S ;

Dohrn, B ;

Bauer, M ;

Lösche, W .

CRITICAL CARE MEDICINE, 2005, 33 (06) :1416-1419

← 1 2 3 4 5 6 7 8 →