Is prolactin the cardinal calciotropic maternal hormone?

被引：54

作者：

Charoenphandhu, Narattaphol ^{[1
,2
]}

Wongdee, Kannikar ^{[2
,3
]}

Krishnamra, Nateetip ^{[1
,2
]}

机构：

[1] Mahidol Univ, Fac Sci, Dept Physiol, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Consortium Calcium & Bone Res COCAB, Bangkok 10400, Thailand

[3] Burapha Univ, Fac Allied Hlth Sci, Chon Buri 20131, Thailand

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 07期

关键词：

TRANSEPITHELIAL CALCIUM-TRANSPORT; BONE-MINERAL DENSITY; VITAMIN-D; CACO-2; MONOLAYER; RECEPTOR ACTIVATOR; PREGNANCY; LACTATION; METABOLISM; ABSORPTION; STIMULATION;

D O I：

10.1016/j.tem.2010.02.002

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

To produce offspring, mothers require a large amount of calcium for fetal growth and milk production. Increased calcium demand leads to enhanced intestinal calcium absorption and stockpiling of bone calcium in pregnancy prior to demineralization in lactation. These coordinated events must be carefully organized by calciotropic hormone(s), but the classical hormones, namely 1,25-dihydroxyvitamin D3, parathyroid hormone and calcitonin, do not appear to be responsible. Plasma prolactin (PRL) levels are elevated during pregnancy and, in view of the presence of PRL receptors in gut, bone and mammary glands, as well as recent evidence of the stimulatory effects of PRL on intestinal calcium transport, bone resorption and mammary calcium secretion, we postulate that PRL is the cardinal calciotropic hormone during pregnancy and lactation. © 2010 Elsevier Ltd.

引用

收藏

页码：395 / 401

页数：7

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