Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS

被引：113

作者：

Kärkkäinen, I

Rybnikova, E

Pelto-Huikko, M

Huovila, APJ ^{[1
]}

机构：

[1] Univ Tampere, Inst Med Technol, Canc Genet Lab, Tampere, Finland

[2] Tampere Univ Hosp, Tampere, Finland

[3] Univ Tampere, Sch Med, Dept Dev Biol, FIN-33101 Tampere, Finland

[4] Univ Tampere, Sch Med, Dept Pathol, FIN-33101 Tampere, Finland

[5] Russian Acad Sci, IP Pavlov Physiol Inst, St Petersburg 196140, Russia

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2000年 / 15卷 / 06期

关键词：

D O I：

10.1006/mcne.2000.0848

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ADAM family of metalloprotease-disintegrins, including enzymes that process TNF-alpha and beta-amyloid precursor protein, has been indicated in neuronal development, but the role of these protease/adhesion/signaling proteins in adult nervous system remains poorly understood. Present study provides a systematic examination of ADAM gene expression in rodent CNS, showing the first quantitative characterization of ADAM mRNA distribution therein. At least II ADAM mRNAs were expressed. Individual ADAM mRNAs and their isoforms showed strikingly different expression patterns. Expression of mRNAs for ADAM10, the putative alpha-secretase, and ADAM17 (TACE), also indicated in APP processing, was further characterized using in situ hybridization. Expression of ADAM10 mRNA was widespread, while ADAM17 showed a more restricted pattern. Altogether, the wide and differential expression of ADAM mRNAs suggests Versatile roles for ADAMs in the adult CNS.

引用

页码：547 / 560

页数：14

共 80 条

[1] Molecular cloning, chromosomal localization, and expression analysis of CYRN1 and CYRN2, two human genes coding for cyritestin, a sperm protein involved in gamete interaction [J].