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Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues

被引：40
作者：
Almohammai, Asheed [1 ]
Rahbarghazi, Reza [2 ,3 ]
Keyhanmanesh, Rana [4 ,5 ,6 ]
Rezaie, Jafar [7 ]
Ahmadi, Mahdi [2 ,4 ,5 ]
机构：
[1] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[2] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Appl Cell Sci, Tabriz, Iran
[4] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran
[5] Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran
[6] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran
[7] Univ Med Sci, Cellular & Mol Med Inst, Solid Tumor Res Ctr, Orumiyeh, Iran
来源：
JOURNAL OF INFLAMMATION-LONDON | 2021年 / 18卷 / 01期
关键词：
Asthma; Exosome biogenesis; CD63; Inflammatory cytokines; Rats;
D O I：
10.1186/s12950-021-00275-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
071005 [微生物学]; 100108 [医学免疫学];
摘要：
Background The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here, we investigated the dynamic biogenesis of the exosomes in the rat model of asthma. Results Our finding showed an increase in the expression of IL-4 and the suppression of IL-10 in asthmatic lung tissues compared to the control samples (p < 0.05). Along with the promotion of IL-4, the protein level of TNF-alpha was induced, showing an active inflammatory status in OVA-sensitized rats. According to our data, the promotion of asthmatic responses increased exosome biogenesis indicated by increased CD63 levels and acetylcholine esterase activity compared to the normal condition (p < 0.05). Conclusion Data suggest that the stimulation of inflammatory response in asthmatic rats could simultaneously increase the paracrine activity of pulmonary cells via the exosome biogenesis. Exosome biogenesis may correlate with the inflammatory response.
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页数：9
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