Alcohol intake and breast cancer risk:: the European Prospective Investigation into Cancer and Nutrition (EPIC)

被引：77

作者：

Tjonneland, Anne

Christensen, Jane

Olsen, Anja

Stripp, Connie

Thomsen, Birthe L.

Overvad, Kim

Peeters, Petra H. M.

van Gils, Carla H.

Bueno-de-Mesquita, H. Bas

Ocke, Marga C.

Thiebaut, Anne

Fournier, Agne S.

Clavel-Chapelon, Francoise

Berrino, Franco

Palli, Domenico

Tumino, Rosario

Panico, Salvatore

Vineis, Paolo

Agudo, Antonio

Ardanaz, Eva

Martinez-Garcia, Carmen

Amiano, Pilar

Navarro, Carmen

Quiros, Jose R.

Key, Tim J.

Reeves, Gillian

Khaw, Kay-Tee

Bingham, Sheila

Trichopoulou, Antonia

Trichopoulos, Dimitrios

Naska, Androniki

Nagel, Gabriele

Chang-Claude, Jenny

Boeing, Heiner

Lahmann, Petra H.

Manjer, Jonas

Wirfalt, Elisabet

Hallmans, Goran

Johansson, Ingegerd

Lund, Eiliv

Skeie, Guri

Hjartaker, Anette

Ferrari, Pietro

Slimani, Nadia

Kaaks, Rudolf

Riboli, Elio

机构：

[1] Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen O, Denmark

[2] Aalborg Hosp, Dept Clin Epidemiol, Aarhus, Denmark

[3] Aarhus Univ Hosp, DK-8000 Aarhus, Denmark

[4] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[5] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[6] Inst Gustave Roussy, INSERM, ERI 20, F-94805 Villejuif, France

[7] NCI, Epidemiol Unit, Milan, Italy

[8] CSPO, Sci Inst Tuscany, Mol & Nutrit Epidemiol Unit, Florence, Italy

[9] Azienda Osped Civile MP, Canc Registry, Ragusa, Italy

[10] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[11] Univ Turin, Dept Canc Epidemiol, Turin, Italy

[12] Catalan Inst Oncol, Epidemiol Unit, Barcelona, Spain

[13] Publ Hlth Inst Navarra, Pamplona, Spain

[14] Andalusian Sch Publ Hlth, Granada, Spain

[15] Dept Publ Hlth Guipuzkoa, San Sebastian, Spain

[16] Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[17] Hlth & Hlth Serv Council, Hlth Informat Unit, Oviedo, Spain

[18] Univ Oxford, Canc Res UK, Epidemiol Unit, Oxford, England

[19] Univ Cambridge, Sch Clin Med, Dept Publ Hlth & Primary Care, Cambridge, England

[20] MRC, Dunn Human Nutr Unit, Cambridge, England

[21] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[22] German Canc Res Ctr, Div Clin Epidemiol, D-6900 Heidelberg, Germany

[23] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[24] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[25] Lund Univ, Dept Clin Sci, Malmo, Sweden

[26] Univ Hosp No Sweden, Umea, Sweden

[27] Univ Tromso, Inst Community Med, Tromso, Norway

[28] Canc Registry Norway, Inst Populat Based Canc Res, Oslo, Norway

[29] Int Agcy Res Canc, Nutr & Hormones Grp, F-69372 Lyon, France

[30] Univ London Imperial Coll Sci & Technol, Fac Med, Dept Epidemiol & Publ Hlth, London, England

来源：

CANCER CAUSES & CONTROL | 2007年 / 18卷 / 04期

基金：

英国医学研究理事会;

关键词：

alcohol; breast neoplasm; cohort study; hormone replacement therapy;

D O I：

10.1007/s10552-006-0112-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer. Methods Incidence rate ratios (IRRs) based on Cox proportional hazard models were calculated using reported intake of alcohol, recent (at baseline) and lifetime exposure. We adjusted for known risk factors and stratified according to study center as well as potentially modifying host factors. Results During 6.4 years of follow up, 4,285 invasive cases of breast cancer within the age group 35-75 years were identified. For all countries together the IRR per 10 g/day higher recent alcohol intake (continuous) was 1.03 (95% confidence interval (CI): 1.01-1.05). When adjusted, no association was seen between lifetime alcohol intake and risk of breast cancer. No difference in risk was shown between users and non-users of HRT, and there was no significant interaction between alcohol intake and BMI, HRT or dietary folate. Conclusion This large European study supports previous findings that recent alcohol intake increases the risk of breast cancer.

引用

页码：361 / 373

页数：13

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