Chemical and biological investigation of the fungus Pulveroboletus ravenelii

被引：21

作者：

Duncan, CJG

Cuendet, M

Fronczek, FR

Pezzuto, JM

Mehta, RG

Hamann, MT

Ross, SA ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy,Res Inst Pharmaceut Sci, Thad Cochran Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Univ Illinois, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA

[3] Univ Illinois, Dept Surg Oncol, Coll Med, Chicago, IL 60612 USA

[4] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 01期

关键词：

D O I：

10.1021/np0203990

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new compounds, pulveraven A (1) and pulveraven B (2), as well as vulpinic acid (3) and its previously unreported polymorph were isolated from the fruiting body of Pulveroboletus ravenelii. The structures were determined using a combination of NMR, MS, IR, optical rotation, molecular modeling, and X-ray analysis. The isolates were evaluated for antimicrobial activity as well as their potential to inhibit cyclooxygenase (COX) activity and carcinogen-induced preneoplastic lesion formation with mouse mammary organ culture (MMOC).

引用

页码：103 / 107

页数：5

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