Differential use of CREB binding protein coactivator complexes

被引：190

作者：

Kurokawa, R

Kalafus, D

Ogliastro, MH

Kioussi, C

Xu, L

Torchia, J

Rosenfeld, MG

Glass, CK

机构：

[1] Univ Calif San Diego, Dept Med, Div Cellular & Mol Med, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Med, Biomed Sci Grad Program, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA

来源：

SCIENCE | 1998年 / 279卷 / 5351期

关键词：

D O I：

10.1126/science.279.5351.700

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CREB binding protein (CBP) functions as an essential coactivator of transcription factors that are inhibited by the adenovirus early gene product E1A. Transcriptional activation by the signal transducer and activator of transcription-1 (STAT1) protein requires the C/H3 domain in CBP, which is the primary target of E1A inhibition, Here it was found that the C/H3 domain is not required for retinoid acid receptor (RAR) function, nor is it involved in E1A inhibition, Instead, E1A inhibits RAR function by preventing the assembly of CBP-nuclear receptor coactivator complexes, revealing differences in required CBP domains for transcriptional activation by RAR and STAT1.

引用

收藏

页码：700 / 703

页数：4

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