Mice, microbes and models of infection

被引：71

作者：

Buer, J

Balling, R

机构：

[1] German Res Ctr Biotechnol, D-38124 Braunschweig, Germany

[2] Hannover Med Sch, Inst Med Microbiol, D-30625 Hannover, Germany

来源：

NATURE REVIEWS GENETICS | 2003年 / 4卷 / 03期

关键词：

D O I：

10.1038/nrg1019

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We urgently need animal models to study infectious disease. Mice are susceptible to a similar range of microbial infections as humans. Marked differences between inbred strains of mice in their response to pathogen infection can be exploited to analyse the genetic basis of infections. In addition, the genetic tools that are available in the laboratory mouse, and new techniques to monitor the expression of bacterial genes in vivo, make it the principal experimental animal model for studying mechanisms of infection and immunity.

引用

页码：195 / 205

页数：11

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