Ca2+ channel β-subunits:: structural insights AID our understanding

被引：85

作者：

Richards, MW

Butcher, AJ

Dolphin, AC

机构：

[1] UCL, Dept Pharmacol, Mol & Cellular Neurosci Lab, London WC1E 6BT, England

[2] Univ London Birkbeck Coll, Sch Crystallog, London WC1E 7HX, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2004年 / 25卷 / 12期

关键词：

D O I：

10.1016/j.tips.2004.10.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It has taken 17 years from the first identification of a voltage-gated Ca2+ channel (Ca-V) beta-subunit as a band on a gel following purification of skeletal muscle dihydropyridine (DHP) receptors in 1987 to the publication of key information on the structures of Ca2+ channel beta-subunits. Three recent X-ray crystallographic studies have now solved the structures of the core domains of three Ca2+ channel beta-subunits. In this article, the properties of these cytoplasmic auxiliary subunits will first be summarized. Then the Ca(V)beta structures and the information they provide regarding how these proteins interact with the Ca(V)alpha1 subunit will be discussed and the possible implications of these new data for G-protein modulation of Ca2+ channels will be examined.

引用

收藏

页码：626 / 632

页数：7

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