Nucleic acid base pair dynamics: The impact of sequence and structure using free-energy calculations

被引：42

作者：

Giudice, E ^{[1
]}

Lavery, R ^{[1
]}

机构：

[1] CNRS, UPR 9080, Inst Biol Physicochim, Lab Biochim Theor, F-75005 Paris, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 17期

关键词：

D O I：

10.1021/ja034095r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Molecular dynamics free-energy calculations of base pair opening within double helical DNA and RNA are used to explain why A-tracts (oligo-adenine repeats) greatly increase the lifetimes of AT base pairs, whereas the structural and the chemical changes involved in passing from B-DNA to A-RNA have comparatively small effects. Copyright © 2003 American Chemical Society.

引用

页码：4998 / 4999

页数：2

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