NSAID-gastroenteropathy: new aspects of pathogenesis and prevention

被引：51

作者：

Blackler, Rory W. ^{[1
]}

Gemici, Burcu ^{[2
]}

Manko, Anna ^{[1
]}

Wallace, John L. ^{[3
,4
]}

机构：

[1] McMaster Univ, Dept Med, Hamilton, ON, Canada

[2] Near East Univ, Nicosia, Cyprus

[3] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada

[4] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

来源：

CURRENT OPINION IN PHARMACOLOGY | 2014年 / 19卷

基金：

加拿大健康研究院;

关键词：

SMALL-INTESTINAL INJURY; PROTON PUMP INHIBITORS; HYDROGEN-SULFIDE; SMALL-BOWEL; BILE; ENTEROPATHY; INDOMETHACIN; BACTERIA; LESIONS; RATS;

D O I：

10.1016/j.coph.2014.05.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nonsteroidal anti-inflammatory drugs (NSAIDs) remain among the most commonly used medications because of their effectiveness in reducing pain and inflammation. Inhibitors of gastric acid secretion can substantially reduce the damaging effects of NSAIDs in the stomach and duodenum. However, there are no proven effective preventative or curative treatments for NSAID-induced enteropathy. In recent years, substantial progress has been made in better understanding the pathogenesis of NSAID-enteropathy, and in particular the interplay of enteric bacteria, bile and the enterohepatic recirculation of the NSAIDs. Moreover, it is becoming clear that suppression of gastric acid secretion significantly worsens NSAID-enteropathy.

引用

页码：11 / 16

页数：6

共 33 条

[1] The interaction between bacteria and bile
Begley, M
Gahan, CGM
Hill, C
[J]. FEMS MICROBIOLOGY REVIEWS, 2005, 29 (04) : 625 - 651
[2] Gastrointestinal-Sparing Effects of Novel NSAIDs in Rats with Compromised Mucosal Defence
Blackler, Rory
Syer, Stephanie
Bolla, Manlio
Ongini, Ennio
Wallace, John L.
[J]. PLOS ONE, 2012, 7 (04):
[3] Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs
Fiorucci, S
Antonelli, E
Distrutti, E
Rizzo, G
Mencarelli, A
Orlandi, S
Zanardo, R
Renga, B
Di Sante, M
Morelli, A
Cirino, G
Wallace, JL
[J]. GASTROENTEROLOGY, 2005, 129 (04) : 1210 - 1224
[4] Graham DY, 2005, CLIN GASTROENTEROL H, V3, P55, DOI 10.1016/S1542-3565(04)00603-2
[5] Hagiwara Mari, 2004, Journal of Medical Investigation, V51, P43, DOI 10.2152/jmi.51.43
[6] The continuing importance of bile acids in liver and intestinal disease
Hofmann, AF
[J]. ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (22) : 2647 - 2658
[7] Role of bile in pathogenesis of indomethacin-induced enteropathy
Jacob, Molly
Foster, Russel
Sigthorsson, Gudmundur
Simpson, Robert
Bjarnason, Ingvar
[J]. ARCHIVES OF TOXICOLOGY, 2007, 81 (04) : 291 - 298
[8] Time Trends and Impact of Upper and Lower Gastrointestinal Bleeding and Perforation in Clinical Practice
Lanas, Angel
Garcia-Rodriguez, Luis A.
Polo-Tomas, Monica
Ponce, Marta
Alonso-Abreu, Inmaculada
Angeles Perez-Aisa, Maria
Perez-Gisbert, Javier
Bujanda, Luis
Castro, Manuel
Munoz, Maria
Rodrigo, Luis
Calvet, Xavier
Del-Pino, Dolores
Garcia, Santiago
[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2009, 104 (07) : 1633 - 1641
[9] Pharmacologic Targeting of Bacterial β-Glucuronidase Alleviates Nonsteroidal Anti-Inflammatory Drug-Induced Enteropathy in Mice
LoGuidice, Amanda
Wallace, Bret D.
Bendel, Lauren
Redinbo, Matthew R.
Boelsterli, Urs A.
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 341 (02) : 447 - 454
[10] Increased Incidence of Small Intestinal Bacterial Overgrowth During Proton Pump Inhibitor Therapy
Lombardo, Lucio
Foti, Monica
Ruggia, Olga
Chiecchio, Andrea
[J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2010, 8 (06) : 504 - 508

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