Postantibiotic effect and postantibiotic sub-MIC effect of levofloxacin compared to those of ofloxacin, ciprofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci

被引：30

作者：

Spangler, SK

Lin, GR

Jacobs, MR

Appelbaum, PC

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol Clin Microbiol, Hershey, PA 17033 USA

[2] Case Western Reserve Univ, Dept Pathol Clin Microbiol, Cleveland, OH 44106 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 05期

关键词：

D O I：

10.1128/AAC.42.5.1253

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The postantibiotic effect (PAE) (10 times the MIC of quinolones, 5 times the MIC of macrolides) and postantibiotic sub-MIC effect (PAE-SME) at 0.125, 0.25, and 0.5 times the MIC were determined for levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci, Quinolone PAEs ranged between 0.5 and 6.5 h, and macrolide PAEs ranged between 1 and 6 h, Measurable PAE-SMEs (in hours) at the three concentrations were 1 to 5, 1 to 8, and 1 to 8, respectively, for quinolones and 1 to 8, 1 to 8, and 1 to 6, respectively, for macrolides.

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页码：1253 / 1255

页数：3

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