GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis

被引：25

作者：

Comer, JE

Galindo, CL

Chopra, AK

Peterson, JW

机构：

[1] Univ Texas, Dept Microbiol & Immunol, Med Branch, Galveston, TX 77555 USA

[2] Univ Texas, Dept Expt Pathol, Med Branch, Galveston, TX USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 03期

关键词：

D O I：

10.1128/IAI.73.3.1879-1885.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 It, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.

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页码：1879 / 1885

页数：7

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