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Deletion mapping of chromosome 10 in human glioma

被引：36
作者：
Sonoda, Y
Murakami, Y
Tominaga, T
Kayama, T
Yoshimoto, T
Sekiya, T
机构：
[1] NATL CANC CTR,RES INST,DIV ONCOGENE,CHUO KU,TOKYO 104,JAPAN
[2] TOHOKU UNIV,SCH MED,DEPT NEUROSURG,AOBA KU,SENDAI,MIYAGI 980,JAPAN
来源：
JAPANESE JOURNAL OF CANCER RESEARCH | 1996年 / 87卷 / 04期
关键词：
human glioma; deletion map; LOH on chromosome 10; microsatellite sequences; tumor suppressor gene;
D O I：
10.1111/j.1349-7006.1996.tb00231.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types, We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q, Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas.
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页码：363 / 367
页数：5
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