Insulin-producing cells derived from stem/progenitor cells: therapeutic implications for diabetes mellitus

被引：14

作者：

Hori, Yuichi ^{[1
]}

机构：

[1] Kobe Univ, Dept Surg, Div Hepatobiliary Pancreat Surg, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

MEDICAL MOLECULAR MORPHOLOGY | 2009年 / 42卷 / 04期

关键词：

Insulin-producing cell (IPC); Pancreatic stem cell; Diabetes mellitus; CD133; ES cells; iPS cells; EMBRYONIC STEM-CELLS; PANCREATIC BETA-CELLS; ADULT-MOUSE PANCREAS; PROGENITOR CELLS; DEFINITIVE ENDODERM; PROMOTES DIFFERENTIATION; ISLET TRANSPLANTATION; ENDOCRINE-CELLS; BONE-MARROW; IN-VITRO;

D O I：

10.1007/s00795-009-0471-x

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

One of the most common diseases of the pancreas is diabetes mellitus. The current treatment of exogenous insulin supply is not fully capable of achieving tight control of glucose regulation, leading to long-term complications. Hence, recent success in islet transplantation-based therapies for diabetes mellitus and the extreme shortage of pancreatic islets have motivated recent efforts to develop renewable sources of islet-replacement tissue. Of clinical interest, I review the recent progress on stem cell-based strategies for diabetes in view of regenerative medicine.

引用

页码：195 / 200

页数：6

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