The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

被引：910

作者：

Schroder, Kate ^{[1
,2
]}

Zhou, Rongbin ^{[1
]}

Tschopp, Jurg ^{[1
]}

机构：

[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

[2] Monash Univ, Monash Inst Med Res, Clayton, Vic 3800, Australia

来源：

SCIENCE | 2010年 / 327卷 / 5963期

基金：

英国医学研究理事会; 瑞士国家科学基金会;

关键词：

BETA-CELL APOPTOSIS; THIOREDOXIN-INTERACTING PROTEIN; TYPE-2; DIABETES-MELLITUS; HUMAN PANCREATIC-ISLETS; NALP3; INFLAMMASOME; CRYOPYRIN INFLAMMASOME; INNATE IMMUNITY; RECEPTOR; INTERLEUKIN-1-BETA; GLUCOSE;

D O I：

10.1126/science.1184003

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interleukin-1 beta (IL-1 beta), reactive oxygen species (ROS), and thioredoxin-interacting protein (TXNIP) are all implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Here we review mechanisms directing IL-1 beta production and its pathogenic role in islet dysfunction during chronic hyperglycemia. In doing so, we integrate previously disparate disease-driving mechanisms for IL-1 beta, ROS, and TXNIP in T2DM into one unifying model in which the NLRP3 inflammasome plays a central role. The NLRP3 inflammasome also drives IL-1 beta maturation and secretion in another disease of metabolic dysregulation, gout. Thus, we propose that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.

引用

页码：296 / 300

页数：5

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