A sib-pair regression model of linkage disequilibrium for quantitative traits

被引：12

作者：

Cardon, LR ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

来源：

HUMAN HEREDITY | 2000年 / 50卷 / 06期

关键词：

linkage disequilibrium; quantitative trait; sib pair;

D O I：

10.1159/000022940

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A multiple-regression model is described for the detection of linkage disequilibrium in quantitative trait loci, The model is developed for application to large numbers of single nucleotide polymorphism (SNP) markers genotyped on small nuclear families, Parental data are not required by the method, although it provides a direct means to test quantitative trait locus-marker allele association and to determine whether any such association is attributable to linkage disequilibrium or population admixture, Analytical expectations for the regression coefficients are derived, allowing direct interpretation of the parameter estimates, Simulation studies indicate a substantial improvement in power over classical linkage studies of sibling pairs and show the effects of population admixture on the model outcomes, Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：350 / 358

页数：9

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