Molecular cloning, chromosomal localization, and expression of the murine SALL1 ortholog Sall1

被引：34

作者：

Buck, A ^{[1
]}

Archangelo, L ^{[1
]}

Dixkens, C ^{[1
]}

Kohlhase, J ^{[1
]}

机构：

[1] Univ Gottingen, Inst Human Genet, D-37073 Gottingen, Germany

来源：

CYTOGENETICS AND CELL GENETICS | 2000年 / 89卷 / 3-4期

关键词：

D O I：

10.1159/000015598

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SALL1 has been identified as one of now three human homologs of the region specific homeotic gene spall (sal) of Drosophila, which encodes a zinc finger protein of characteristic structure. Mutations of SALL1 on chromosome 16q12.1 cause Townes-Brocks syndrome (TBS, OMIM no. 107480). In order to facilitate functional studies of this gene in a model organism, we searched for the murine homolog of SALL1. Hero we report the genomic cloning, chromosome mapping, and partial expression analysis of the gene Sall1. Sequence comparison, Northern blot hybridization as well as the conserved chromosome location on the homologous mouse chromosome indicate that we have indeed isolated the murine homolog of SALL1. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：150 / 153

页数：4

共 20 条

[1] A gene complex acting downstream of dpp in Drosophila wing morphogenesis [J].

deCelis, JF ;

Barrio, R ;

Kafatos, FC .

NATURE, 1996, 381 (6581) :421-424

[2] HEAD AND TAIL DEVELOPMENT OF THE DROSOPHILA EMBRYO INVOLVES SPALT, A NOVEL HOMEOTIC GENE [J].

JURGENS, G .

EMBO JOURNAL, 1988, 7 (01) :189-196

[3] Molecular cloning of a SALL1-related pseudogene and mapping to chromosome Xp11.2 [J].

Kohlhase, J ;

Köhler, A ;

Jäckle, H ;

Engel, W ;

Stick, R .

CYTOGENETICS AND CELL GENETICS, 1999, 84 (1-2) :31-34

[4] SALL3, a New member of the human spalt-like gene family, maps to 18q23 [J].

Kohlhase, J ;

Hausmann, S ;

Stojmenovic, G ;

Dixkens, C ;

Bink, K ;

Schulz-Schaeffer, W ;

Altmann, M ;

Engel, W .

GENOMICS, 1999, 62 (02) :216-222

[5] Molecular analysis of SALL1 mutations in Townes-Brocks syndrome [J].

Kohlhase, J ;

Taschner, PEM ;

Burfeind, P ;

Pasche, B ;

Newman, B ;

Blanck, C ;

Breuning, MH ;

ten Kate, LP ;

Maaswinkel-Mooy, P ;

Mitulla, B ;

Seidel, J ;

Kirkpatrick, SJ ;

Pauli, RM ;

Wargowski, DS ;

Devriendt, K ;

Proesmans, W ;

Gabrielli, O ;

Coppa, GV ;

Wesby-van Swaay, E ;

Trembath, RC ;

Schinzel, AA ;

Reardon, W ;

Seemanova, E ;

Engel, W .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (02) :435-445

[6] Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndrome [J].

Kohlhase, J ;

Wischermann, A ;

Reichenbach, H ;

Froster, U ;

Engel, W .

NATURE GENETICS, 1998, 18 (01) :81-83

[7] Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt [J].

Kohlhase, J ;

Schuh, R ;

Dowe, G ;

Kuhnlein, RP ;

Jackle, H ;

Schroeder, B ;

SchulzSchaeffer, W ;

Kretzschmar, HA ;

Kohler, A ;

Muller, U ;

RaabVetter, M ;

Burkhardt, E ;

Engel, W ;

Stick, R .

GENOMICS, 1996, 38 (03) :291-298

[8] Genomic cloning, chromosomal mapping, and expression analysis Msal-2 [J].

Kohlhase, J ;

Altmann, M ;

Archangelo, L ;

Dixkens, C ;

Engel, W .

MAMMALIAN GENOME, 2000, 11 (01) :64-68

[9]

Kuhnlein RP, 1996, DEVELOPMENT, V122, P2215

[10] SPALT ENCODES AN EVOLUTIONARILY CONSERVED ZINC-FINGER PROTEIN OF NOVEL STRUCTURE WHICH PROVIDES HOMEOTIC GENE-FUNCTION IN THE HEAD AND TAIL REGION OF THE DROSOPHILA EMBRYO [J].

KUHNLEIN, RP ;

FROMMER, G ;

FRIEDRICH, M ;

GONZALEZGAITAN, M ;

WEBER, A ;

WAGNERBERNHOLZ, JF ;

GEHRING, WJ ;

JACKLE, H ;

SCHUH, R .

EMBO JOURNAL, 1994, 13 (01) :168-179

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