Seprase complexes in cellular invasiveness

被引:101
作者
Chen, WT [1 ]
Kelly, T
机构
[1] SUNY Stony Brook, Dept Med, Div Neoplast Dis, Stony Brook, NY 11794 USA
[2] Arkansas Canc Res Ctr, Dept Pathol, Little Rock, AR 72205 USA
关键词
seprase; FAP alpha; DPP4; invasion; angiogenesis; metastasis; wound healing;
D O I
10.1023/A:1023055600919
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A group of type II integral serine proteases, including dipeptidyl peptidase IV (DPP4/CD26), seprase/fibroblast activation protein alpha (FAPalpha) and related type II transmembrane prolyl serine peptidases, exert their mechanisms of action on the cell surface. DPP4 and seprase exhibit multiple functions due to their abilities to form complexes with each other and to interact with other membrane-associated molecules. Localization of the protease complexes at cell surface protrusions, called invadopodia, may have a prominent role in processing soluble factors (including chemokines and neuropeptide Y) and in degrading locally extracellular matrix components, that are essential to the cell migration and matrix invasion occurring during tumor invasion, angiogenesis and metastasis.
引用
收藏
页码:259 / 269
页数:11
相关论文
共 80 条
[1]   Two highly conserved glutamic acid residues in the predicted β propeller domain of dipeptidyl peptidase IV are required for its enzyme activity [J].
Abbott, CA ;
McCaughan, GW ;
Gorrell, MD .
FEBS LETTERS, 1999, 458 (03) :278-284
[2]   GENOMIC ORGANIZATION, EXACT LOCALIZATION, AND TISSUE EXPRESSION OF THE HUMAN CD26 (DIPEPTIDYL PEPTIDASE-IV) GENE [J].
ABBOTT, CA ;
BAKER, E ;
SUTHERLAND, GR ;
MCCAUGHAN, GW .
IMMUNOGENETICS, 1994, 40 (05) :331-338
[3]   Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted β propeller domain [J].
Abbott, CA ;
McCaughan, GW ;
Levy, MT ;
Church, WB ;
Gorrell, MD .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 266 (03) :798-810
[4]   A 170-KDA MEMBRANE-BOUND PROTEASE IS ASSOCIATED WITH THE EXPRESSION OF INVASIVENESS BY HUMAN-MALIGNANT MELANOMA-CELLS [J].
AOYAMA, A ;
CHEN, WT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) :8296-8300
[5]   Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes:: dependence on β1 integrins and the cytoskeleton [J].
Artym, VV ;
Kindzelskii, AL ;
Chen, WT ;
Petty, HR .
CARCINOGENESIS, 2002, 23 (10) :1593-1601
[6]   OLIGOPEPTIDASES, AND THE EMERGENCE OF THE PROLYL OLIGOPEPTIDASE FAMILY [J].
BARRETT, AJ ;
RAWLINGS, ND .
BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1992, 373 (07) :353-360
[7]   Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collagens [J].
Bermpohl, F ;
Löster, K ;
Reutter, W ;
Baum, O .
FEBS LETTERS, 1998, 428 (03) :152-156
[8]   FIBRONECTIN-DEGRADING PROTEASES FROM THE MEMBRANES OF TRANSFORMED-CELLS [J].
CHEN, JM ;
CHEN, WT .
CELL, 1987, 48 (02) :193-203
[9]  
Chen Wen-Tien, 1994, Journal of Tissue Culture Methods, V16, P177, DOI 10.1007/BF01540646
[10]   Specialized surface protrusions of invasive cells, invadopodia and lamellipodia, have differential MT1-MMP, MMP-2, and TIMP-2 localization [J].
Chen, WT ;
Wang, JY .
INHIBITION OF MATRIX METALLOPROTEINASES: THERAPEUTIC APPLICATIONS, 1999, 878 :361-371