Maternal exposure to prescription and non prescription pharmaceuticals or drugs of abuse and risk of craniosynostosis

被引:66
作者
Gardner, JS
Guyard-Boileau, B
Alderman, BW
Fernbach, SK
Greene, C
Mangione, EJ
机构
[1] Univ Washington, Dept Pharm, Seattle, WA 98195 USA
[2] Hop St Antoine, F-75571 Paris, France
[3] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[4] Childrens Mem Hosp, Dept Radiol, Chicago, IL 60614 USA
[5] Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80262 USA
[6] Childrens Hosp, Denver, CO 80218 USA
[7] Colorado Dept Hlth, Dis Control & Environm Epidemiol Div, Denver, CO 80220 USA
关键词
craniosynostosis; nitrosatable drugs; pharmacoepidemiology; maternal exposure;
D O I
10.1093/ije/27.1.64
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background The pre-and peri-natal drug exposures reported by women participating in a case-control study of children in Colorado were examined for association with infant craniosynostosis. Methods Mothers of case and control children underwent a standardized telephone interview and obstetric and newborn medical record review. The interview included questions on the use of prescription and non-prescription drugs, nutritional supplements, recreational and drugs of abuse. The mother's obstetric record was abstracted for information about pharmacologic agents taken before and during the antepartum period. Reults There were no statistically significant risk ratios associating craniosynostosis with prenatal exposure to hydantoin, valproic acid, or cocaine. Mothers of four case children and one control child reported specific exposure to retinoic acid. There were no statisically significant increases in the odds ratio (OR) for any suture type among children exposed to hypoxigenic agents, sympathomimetic or parasympatholytic agents, or metal-containing agents. The OR was 1.87 (lower bound of the two-sided 95% test-based confidence interval (CI): 1.08) among children with sagittal/lambdoid suture synostosis who were exposed to nitrosatable drugs chlorpheniramine, chlordiazepoxide, and nitrofurantoin compared to controls. Conclusions Certain nitrosatable drugs may be associated with increased risk of infant sagittal/lambdoid craniosynostosis. A possible mechanism related to ischaemia/reperfusion injury is suggested.
引用
收藏
页码:64 / 67
页数:4
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