Human interferons alpha, beta and omega

被引：152

作者：

Bekisz, J ^{[1
]}

Schmeisser, H ^{[1
]}

Hernandez, J ^{[1
]}

Goldman, ND ^{[1
]}

Zoon, KC ^{[1
]}

机构：

[1] NCI, Canc Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

GROWTH FACTORS | 2004年 / 22卷 / 04期

关键词：

type I interferons; human IFN alpha receptor; cytokines; polypeptide;

D O I：

10.1080/08977190400000833

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-alpha/beta with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.

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收藏

页码：243 / 251

页数：9

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