Interplay between Neuroimmunoendocrine Systems during Post-Traumatic Stress Disorder: A Minireview

被引：51

作者：

Bauer, Moises E. ^{[1
,3
]}

Wieck, Andrea

Lopes, Rodrigo P. ^{[5
]}

Teixeira, Antonio L. ^{[4
]}

Grassi-Oliveira, Rodrigo ^{[2
]}

机构：

[1] Pontificia Univ Catolica Rio Grande do Sul, Lab Cellular & Mol Immunol, Inst Biomed Res, BR-90610000 Porto Alegre, RS, Brazil

[2] Pontificia Univ Catolica Rio Grande do Sul, Fac Psychol, BR-90610000 Porto Alegre, RS, Brazil

[3] Pontificia Univ Catolica Rio Grande do Sul, Fac Biosci, BR-90610000 Porto Alegre, RS, Brazil

[4] Univ Fed Minas Gerais, Dept Internal Med, Sch Med, Belo Horizonte, MG, Brazil

[5] BD Biosci, Sao Paulo, Brazil

来源：

NEUROIMMUNOMODULATION | 2010年 / 17卷 / 03期

关键词：

Post-traumatic stress disorder; Cortisol; Hypocortisolism; Cytokines; Inflammation; Lymphocytes; ABUSE; CHILDHOOD; WOMEN; RESPONSES; IMMUNE; WAR;

D O I：

10.1159/000258721

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Early life stress has been suggested to mediate vulnerability to affective disorders. Traumatic events experienced in childhood such as sexual abuse and/or physical neglect may lead to psychiatric diseases in adult life, including post-traumatic stress disorder ( PTSD). Previous studies have focused on adult traumatic events and very little is known regarding the long-term physiological effects of early life stress. Here, we review the complex interplay between most important cognitive, neuroendocrine and immunological changes reported in PTSD, focusing on long-term implications of childhood maltreatment. PTSD has been associated with significant biological changes related to impaired cognitive functions, attenuated hypothalamic-pituitary-adrenal (HPA) axis function (hypocortisolism) and activation of innate immune responses (low-grade inflammation). Copyright (C) 2010 S. Karger AG, Basel

引用

页码：192 / 195

页数：4

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