The synthesis of the novel adenosine agonists, exo- and endo-N-6-(5,6-epoxynorborn-2-yl)adenosine

被引：13

作者：

Scammells, PJ

Baker, SP

Bellardinelli, L

Olsson, RA

Russell, RA

Wright, DMJ

机构：

[1] UNIV FLORIDA,COLL MED,HLTH SCI CTR,DEPT PHARMACOL,GAINESVILLE,FL 32610

[2] UNIV FLORIDA,COLL MED,HLTH SCI CTR,DEPT MED,GAINESVILLE,FL 32610

[3] UNIV S FLORIDA,DEPT INTERNAL MED,TAMPA,FL 33612

来源：

TETRAHEDRON | 1996年 / 52卷 / 13期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/0040-4020(96)00144-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both racemic exo and endo isomers of N-6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the Al adenosine receptor. Crucial to the preparation of these compounds is the synthesis of exo and endo norbornenylamines which are accessed through an optimised Curtius rearrangement.

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收藏

页码：4735 / 4744

页数：10

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