Characteristics and analysis of normal and leukemic stem cells: current concepts and future directions

被引：34

作者：

Brendel, C ^{[1
]}

Neubauer, A ^{[1
]}

机构：

[1] Klinikum Philipps Univ Marburg, Dept Hematol Oncol Immunol, D-35043 Marburg, Germany

来源：

LEUKEMIA | 2000年 / 14卷 / 10期

关键词：

stem cell; acute myeloid leukemia; CD34; antigen; mutation; cytogenetic aberration;

D O I：

10.1038/sj.leu.2401907

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemias (AML) are considered to be clonal disorders involving early hematopoietic progenitor cells. The recent advances in characterization of early stem cells give rise to the question whether it is possible to distinguish healthy progenitors from cells of the leukemic clone in leukemia patients. Differences and similarities in phenotype, genotype and biology are described for leukemic cells and normal hematological progenitors. Recent new insights into human stem cell development offer the perspective that distinction between benign and malignant progenitors might be possible in the future at a very early stage of maturation.

引用

页码：1711 / 1717

页数：7

共 83 条

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