Patients With High-Bone-Mass Phenotype Owing to Lrp5-T253I Mutation Have Low Plasma Levels of Serotonin

被引：49

作者：

Frost, Morten ^{[1
]}

Andersen, Tom Erenskjold ^{[1
]}

Yadav, Vijay ^{[2
]}

Brixen, Kim ^{[1
]}

Karsenty, Gerard ^{[2
]}

Kassem, Moustapha ^{[1
,3
]}

机构：

[1] Univ So Denmark, Ctr Med Biotechnol, Lab Mol Endocrinol KMEB, Dept Endocrinol & Metab, Odense, Denmark

[2] Columbia Univ, Dept Genet & Dev, New York, NY USA

[3] King Saud Univ, Coll Med, Dept Anat, Stem Cell Unit, Riyadh 11461, Saudi Arabia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2010年 / 25卷 / 03期

关键词：

SEROTONIN; LRP5; HIGH BONE MASS; T2531; BONE FORMATION; REUPTAKE INHIBITORS; DENSITY; RISK;

D O I：

10.1002/jbmr.44

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The Lrp5 gene is a major determinant of bone mass accrual. It has been demonstrated recently to achieve this function by hampering the synthesis of gut-derived serotonin, which is a powerful inhibitor of bone formation. In this study we analyzed plasma serotonin levels in patients with a high-bone-mass (HBM) phenotype owing to gain-of-function mutation of Lrp5 (T2531). A total of 9 HBM patients were compared with 18 sex- and age-matched controls. In HBM patients, the serotonin concentrations in platelet-poor plasma were significantly lower than in the controls (mean +/- SEM: 2.16 +/- 0.28 ng/mL versus 3.51 +/- 0.49 ng/mL, respectively, p <.05). Our data support the hypothesis that circulating serotonin levels mediate the increased bone mass resulting from gain-of-function mutations in Lrp5 in humans. (C) 2010 American Society for Bone and Mineral Research.

引用

页码：673 / 675

页数：3

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