The prevalence of and risk factors for atopy in early childhood: A whole population birth cohort study

被引:301
作者
Tariq, SM [1 ]
Matthews, SM [1 ]
Hakim, EA [1 ]
Stevens, M [1 ]
Arshad, SH [1 ]
Hide, DW [1 ]
机构
[1] St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport PO30 5TG, Wight, England
关键词
atopy; family history; cord IgE; asthma; eczema; allergic rhinitis; birth cohort; skin prick test;
D O I
10.1016/S0091-6749(98)70164-2
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Objectives: A birth cohort was followed-up to age 4 years to record the development of allergic disorders and to study the influence of genetic and environmental factors. Methods: Information on family history and environmental factors was obtained at birth, and serum cord IgE was measured. At age 4 years, 1218 children were reviewed. Results: By age 4 years, 27% of the children had symptoms of allergic disease. Period prevalence of asthma increased from 8.7% in infancy to 14.9% at 4 years; Family history of atopy was the single most important risk factor for atopy in children. Sibling atopy was a stronger predictor of clinical disease than maternal dr paternal atopy, whereas paternal atopy, male sex, and high cord IgE were significant for the development of allergen sensitization. Children of asthmatic mothers were three times more likely to have asthma (odds ratio [OR]: 3.0, 95% confidence interval [CI]: 1.6-5.8) and rhinitis (OR: 2.9, CI: 1.1-7.4). Formula feeding before 3 months of age predisposed to asthma at age 4 years (OR: 1.8, CI: 1.2-2.6). The effect of maternal smoking on childhood wheeze seen at 1 and 2 years was lost by age 4, except for a subgroup with negative skin test responses (nonatopic asthma). Less than half (46%) of the infantile wheezers were still wheezing at 4 years of age. Conclusion: Family history of atopy remains the most important risk factor for atopy in children, but other markers can be identified with a potential for Intervention at an early age.
引用
收藏
页码:587 / 593
页数:7
相关论文
共 36 条
[1]   EFFECT OF ENVIRONMENTAL-FACTORS ON THE DEVELOPMENT OF ALLERGIC DISORDERS IN INFANCY [J].
ARSHAD, SH ;
HIDE, DW .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 90 (02) :235-241
[2]   THE EFFECT OF GENETIC AND ENVIRONMENTAL-FACTORS ON THE PREVALENCE OF ALLERGIC DISORDERS AT THE AGE OF 2 YEARS [J].
ARSHAD, SH ;
STEVENS, M ;
HIDE, DW .
CLINICAL AND EXPERIMENTAL ALLERGY, 1993, 23 (06) :504-511
[3]  
ARSHAD SH, 1991, BRIT J CLIN PRACT, V45, P88
[4]  
BJORKSTEN F, 1980, CLIN ALLERGY, V10, P581
[5]  
BURR ML, 1993, EPIDEMIOLOGY CLIN AL, P80
[6]   PREDICTIVE VALUE OF CORD BLOOD IGE IN THE DEVELOPMENT OF ATOPIC DISEASE AND ROLE OF BREAST-FEEDING IN ITS PREVENTION [J].
CHANDRA, RK ;
PURI, S ;
CHEEMA, PS .
CLINICAL ALLERGY, 1985, 15 (06) :517-522
[7]   PARENTAL SMOKING, BREAST-FEEDING, AND RESPIRATORY-INFECTION IN DEVELOPMENT OF ALLERGIC DISEASES [J].
COGSWELL, JJ ;
MITCHELL, EB ;
ALEXANDER, J .
ARCHIVES OF DISEASE IN CHILDHOOD, 1987, 62 (04) :338-344
[8]   IGE SCREENING IN 1701 NEWBORN-INFANTS AND THE DEVELOPMENT OF ATOPIC DISEASE DURING INFANCY [J].
CRONER, S ;
KJELLMAN, NIM ;
ERIKSSON, B ;
ROTH, A .
ARCHIVES OF DISEASE IN CHILDHOOD, 1982, 57 (05) :364-368
[9]  
*DCD, 1990, MORBIDITY MORTALITY, V39, P493
[10]   The influence of breast and artificial feeding on infantile eczema [J].
Grulee, CG ;
Sanford, HN .
JOURNAL OF PEDIATRICS, 1936, 9 :223-225