PACdb: a database for cell-based pharmacogenomics

被引：35

作者：

Gamazon, Eric R. ^{[1
]}

Duan, Shiwei ^{[1
,6
]}

Zhang, Wei ^{[1
]}

Huang, Rong Stephanie ^{[1
]}

Kistner, Emily O. ^{[1
,5
]}

Dolan, Mary Eileen ^{[1
,3
,4
]}

Cox, Nancy J. ^{[1
,2
]}

机构：

[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

[3] Univ Chicago, Comm Clin Pharmacol & Pharmacogenom, Chicago, IL 60637 USA

[4] Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA

[5] Med Univ S Carolina, Dept Med, Div Biostat & Epidemiol, Charleston, SC 29425 USA

[6] ASTAR, Singapore Inst Clin Sci, Singapore, Singapore

来源：

PHARMACOGENETICS AND GENOMICS | 2010年 / 20卷 / 04期

关键词：

drug response; gene expression; HapMap; lymphoblastoid cell line; pharmacogenomics; single nucleotide polymorphism; GENETIC-VARIANTS; INDUCED CYTOTOXICITY; IDENTIFICATION; POPULATION; EXPRESSION;

D O I：

10.1097/FPC.0b013e328337b8d6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have developed Pharmacogenomics And Cell database (PACdb), a results database that makes available relationships between single nucleotide polymorphisms, gene expression, and cellular sensitivity to various drugs in cell-based models to help determine genetic variants associated with drug response. The current version also supports summary analysis on differentially expressed genes between the HapMap samples of European and African ancestry, as well as queries for summary information of correlations between gene expression and pharmacological phenotypes. At present, data generated on the following anticancer agents are included: carboplatin, cisplatin, etoposide, daunorubicin, and cytarabine (Ara-C). The database is also available to assist in the investigation of the effects of potential confounding variables (e.g. cell proliferation rate) in lymphoblastoid cell lines. PACdb will be regularly updated to include more drugs and new datasets (e.g. baseline microRNA levels). PACdb will be linked into PharmGKB to benefit the next wave of pharmacogenetic and pharmacogenomic discovery. Pharmacogenetics and Genomics 20:269-273 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：269 / 273

页数：5

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