The treatment for adolescents with depression study (TADS): Demographic and clinical characteristics

被引:92
作者
March, J
Silva, S
Petrycki, S
Curry, J
Wells, K
Fairbank, J
Burns, B
Domino, M
McNulty, S
Casat, C
Kolker, J
Riedal, K
Goldman, M
Feeny, N
Findling, R
Stull, S
McNamara, N
Weller, E
Robins, M
Weller, R
Jessani, N
Waslick, B
Sweeney, M
Kandel, R
Schoenholz, D
Walkup, J
Ginsburg, G
Kastelic, E
Koo, H
Kratochvil, C
May, D
LaGrone, R
Harrington, M
Albano, AM
Hirsch, G
Knibbs, T
Capili, E
Reinecke, M
Leventhal, B
Nageotte, C
Rogers, G
Pathak, S
Wells, J
Arszman, S
Danielyan, A
Simons, A
Rohde, P
Grimm, J
Nguyen, L
Emslie, G
机构
[1] Duke Clin Res Inst, Durham, NC 27710 USA
[2] Duke Univ, Ctr Med, Dept Psychiat & Behav Sci, NIMH, Rockville, MD USA
[3] Duke Univ, Ctr Med, Duke Clin Res Inst, Rockville, MD USA
[4] Case Western Reserve Univ, Cleveland, OH 44106 USA
[5] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
[6] Columbia Univ, New York, NY 10027 USA
[7] Johns Hopkins Univ, Baltimore, MD 21218 USA
[8] Univ Nebraska, Lincoln, NE 68583 USA
[9] NYU, New York, NY USA
[10] Northwestern Univ, Evanston, IL 60208 USA
[11] Univ Cincinnati, Cincinnati, OH 45221 USA
[12] Univ Oregon, Eugene, OR 97403 USA
[13] Wayne State Univ, Detroit, MI 48202 USA
[14] Univ Pittsburgh, Pittsburgh, PA 15260 USA
[15] Univ N Carolina, Chapel Hill, NC 27515 USA
关键词
D O I
10.1097/01.chi.0000145807.09027.82
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Objective: The Treatment for Adolescents With Depression Study is a multicenter, randomized clinical trial sponsored by the NIMH. This study is designed to evaluate the short- and long-term effectiveness of four treatments for adolescents with major depressive disorder: fluoxetine, cognitive-behavioral therapy, their combination, and, acutely, pill placebo. This report describes the demographic and clinical characteristics of the sample and addresses external validity. Method: Participants are 439 adolescents, aged 12-17 years inclusively, with a primary DSM-IV diagnosis of current major depressive disorder. Baseline data are summarized and compared with those from national samples and previous trials. Results: The sample composition is 54.4% girls, 73.8% white, 12.5% African American, and 8.9% Hispanic. The mean Child Depression Rating Scale-Revised total score is 60.1 (SD = 10.4, range 45-98) with 86.0% experiencing their first major depressive episode. The most common concurrent diagnoses are generalized anxiety disorder (15.3%), attention-deficit/hyperactivity disorder (13.7%), oppositional defiant disorder (13.2%), social phobia (10.7%), and dysthymia (10.5%). Demographic results are consistent with data from national samples and large psychopharmacology trials involving depressed adolescents. Conclusions: The Treatment for Adolescents With Depression Study provides a large, diverse, and representative sample of depressed adolescents that highlights the complexity of major depressive disorder in adolescents and provides a rich source for explicating the effects of moderator and mediator variables on baseline psychopathology and treatment outcome.
引用
收藏
页码:28 / 40
页数:13
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