Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease

被引:162
作者
Ventura, A
Neri, E
Ughi, C
Leopaldi, A
Città, A
Not, T
机构
[1] Univ Trieste, IRCCS Burlo Garofolo, Ist Clin Pediat, Pediat Clin, I-34100 Trieste, Italy
[2] Univ Trieste, IRCCS Burlo Garofolo, Lab Anal, I-34100 Trieste, Italy
[3] Univ Pisa, Dipartimento Pediat, Pisa, Italy
关键词
D O I
10.1067/mpd.2000.107160
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Patients with celiac disease are at high risk of having autoimmune disorders. Moreover, untreated patients with celiac disease have been found to have a higher than expected prevalence of organ-specific autoantibodies. In a prospective study of 90 patients with celiac disease, we found that the prevalence of diabetes and thyroid-related serum antibodies was 11.1% and 14.4%, respectively. Like antiendomysium autoantibodies, these organ-specific antibodies seem to be gluten-dependent and tend to disappear during a gluten-free diet.
引用
收藏
页码:263 / 265
页数:3
相关论文
共 12 条
[1]   Usefulness of screening program for celiac disease in autoimmune thyroiditis [J].
Berti, I ;
Trevisiol, C ;
Tommasini, A ;
Città, A ;
Neri, E ;
Geatti, O ;
Giammarini, A ;
Ventura, A ;
Not, T .
DIGESTIVE DISEASES AND SCIENCES, 2000, 45 (02) :403-406
[2]   IMMUNOLOGY AND DIABETES WORKSHOP - REPORT ON THE 3RD INTERNATIONAL (STAGE-3) WORKSHOP ON THE STANDARDIZATION OF CYTOPLASMIC ISLET CELL ANTIBODIES HELD IN NEW-YORK, NEW-YORK, OCTOBER 1987 [J].
BOITARD, C ;
BONIFACIO, E ;
BOTTAZZO, GF ;
GLEICHMANN, H ;
MOLENAAR, J .
DIABETOLOGIA, 1988, 31 (07) :451-452
[3]  
BONAMICO M, 1997, J PEDIAT GASTROENTER, V24, P467
[4]   CELIAC-DISEASE AND AUTOIMMUNE THYROID-DISEASE [J].
COUNSELL, CE ;
TAHA, A ;
RUDDELL, WSJ .
GUT, 1994, 35 (06) :844-846
[5]   Anti-endomysium antibody on human umbilical cord vein tissue: an inexpensive and sensitive diagnostic tool for the screening of coeliac disease [J].
Not, T ;
Citta, A ;
Lucchesi, A ;
Torre, G ;
Martelossi, S ;
Ventura, A .
EUROPEAN JOURNAL OF PEDIATRICS, 1997, 156 (08) :616-618
[6]   Production of antiendomysial antibodies after in-vitro gliadin challenge of small intestine biopsy samples from patients with coeliac disease [J].
Picarelli, A ;
Maiuri, L ;
Frate, A ;
Greco, M ;
Auricchio, S ;
Londei, M .
LANCET, 1996, 348 (9034) :1065-1067
[7]   Coeliac disease and insulin-dependent diabetes mellitus: A causal association? [J].
Pocecco, M ;
Ventura, A .
ACTA PAEDIATRICA, 1995, 84 (12) :1432-1433
[8]  
RAPPAPORT MJ, 1996, J PEDIAT GASTROENTER, V23, P524
[9]  
Revised criteria for diagnosis of coeliac disease, 1990, Arch. Dis. Child, V65, P909, DOI [DOI 10.1136/ADC.65.8.909, 10.1136/adc.65.8.909]
[10]   Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease [J].
Ventura, A ;
Magazzù, G ;
Greco, L .
GASTROENTEROLOGY, 1999, 117 (02) :297-303