Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment

被引：45

作者：

Schildgen, O ^{[1
]}

Schewe, CK

Vogel, M

Däumer, M

Kaiser, R

Weitner, L

Matz, B

Rockstroh, JK

机构：

[1] Univ Bonn, Inst Med Mikrobiol & Immunol, D-5300 Bonn, Germany

[2] Praxis St Georg, D-20099 Hamburg, Germany

[3] Univ Bonn, Med Klin & Poliklin 1, D-53105 Bonn, Germany

[4] Univ Cologne, Inst Virol, D-50931 Cologne, Germany

来源：

AIDS | 2004年 / 18卷 / 17期

关键词：

D O I：

10.1097/00002030-200411190-00014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three HIV-infected patients with chronic hepatitis B (genotype A) were switched to adefovir therapy after unsuccessful lamivudine treatment. Surprisingly, adefovir therapy failed, although none of the virus isolates displayed mutations known to be associated with adefovir resistance (A181V, N236T). In two isolates we identified hepatitis B virus DNA polymerase mutation L217R, in one case we found multiple frameshifts in the same region. In all cases adefovir was replaced by tenofovir, resulting in a significant drop in the viral load.

引用

页码：2325 / 2327

页数：3

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