Nanoparticle Formation of Organic Compounds With Retained Biological Activity

被引：16

作者：

Jacobson, Gunilla B. ^{[1
]}

Shinde, Rajesh ^{[2
,3
,4
]}

McCullough, Rebecca L. ^{[1
]}

Cheng, Nicholas J. ^{[1
]}

Creasman, Adam ^{[2
,3
,4
]}

Beyene, Amanuel ^{[1
]}

Hickerson, Robyn P. ^{[5
]}

Quan, Can ^{[6
]}

Turner, Charlotta ^{[6
]}

Kaspar, Roger L. ^{[5
]}

Contag, Christopher H. ^{[2
,3
,4
]}

Zare, Richard N. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[5] TransDerm Inc, Santa Cruz, CA 95060 USA

[6] Uppsala Univ, Dept Phys & Analyt Chem, SE-75124 Uppsala, Sweden

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 99卷 / 06期

基金：

瑞典研究理事会; 美国国家卫生研究院;

关键词：

siRNA; nanoparticles; supercritical fluids; particle size; biomaterials; stability; antioxidant; QUERCETIN; SIRNA; FORMULATION; MICRONIZATION; FLAVONOIDS; PARTICLES;

D O I：

10.1002/jps.22035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Many pharmaceuticals are formulated as powders to aid drug delivery. A major problem is how to produce powders having high purity, controlled morphology, and retained bioactivity. We demonstrate the use of supercritical carbon dioxide as an antisolvent for meeting this need for two model drug systems, quercetin, a sparingly soluble antioxidant, and short interfering RNA (siRNA), which can silence genes. In both cases we achieve retention of bioactivity as well as a narrow particle size distribution in which the particles are free of impurities. (C) 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:2750-2755, 2010

引用

页码：2750 / 2755

页数：6

共 29 条

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[Anonymous], [No title captured]

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