Crumbs homologue 1 in polarity and blindness

被引：13

作者：

Meuleman, J ^{[1
]}

van de Pavert, SA ^{[1
]}

Wijnholds, J ^{[1
]}

机构：

[1] Royal Netherlands Acad Arts & Sci, Netherlands Ophthalm Res Inst, NL-1105 BA Amsterdam, Netherlands

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

adherens junction; cell adhesion; cell polarity; crumbs homologue 1 (CRB1); leber congenital amaurosis; retinitis pigmentosa;

D O I：

10.1042/BST0320828

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several retinal dystrophies, including retinitis pigmentosa type 12 and Leber congenital amaurosis, are caused by a large variety of mutations in the CRB1 (Crumbs homologue 1) gene. This discovery led to an increased focus on the function of CRB1 and the Drosophila homologue Crumbs. In the present study, we review the current knowledge on Crumbs and its vertebrate homologues, their function in cell polarity and their pathogenicity in retinal degeneration.

引用

页码：828 / 830

页数：3

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