Strategies for drug discovery by targeting sulfation pathways

被引：42

作者：

Hemmerich, S ^{[1
]}

Verdugo, D ^{[1
]}

Rath, VL ^{[1
]}

机构：

[1] Thios Pharmaceuticals, Emeryville, CA 94608 USA

来源：

DRUG DISCOVERY TODAY | 2004年 / 9卷 / 22期

关键词：

D O I：

10.1016/S1359-6446(04)03261-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Posttranslational modifications of proteins such as phosphorylation have been recognized as pivotal modulators of biological activity in healthy and diseased tissues. Sulfation is a key posttranslational modification the role of which in physiology and pathology is only now becoming appreciated. Whereas phosphorylation is central to intracellular signal transduction, sulfation modulates cell-cell and cell-matrix communication. Sulfation involves a class of enzymes known as sulfotransferases, which transfer sulfate from the ATP-like sulfate donor 3'phosphoadenosine-5'phosphosulate to glycoproteins, glycolipids or metabolites. This review focuses on Golgi-localized sulfotransferases, their molecular biology and biochemistry, and strategies towards discovery of sulfotransferase inhibitors that could have potential as therapeutics in inflammation, cancer and infectious diseases.

引用

页码：967 / 975

页数：9

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