C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo

被引:166
作者
Hirvonen, M
Laakso, A
Någren, K
Rinne, JO
Pohjalainen, T
Hietala, J
机构
[1] Turku Univ, Cent Hosp, Turku PET Ctr, Turku 20521, Finland
[2] Univ Turku, Dept Pharmacol & Clin Pharmacol, Turku, Finland
[3] Turku Univ, Cent Hosp, Dept Psychiat, Turku 20521, Finland
关键词
D O I
10.1038/sj.mp.4001561
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1060 / 1061
页数:2
相关论文
共 7 条
[1]   Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor [J].
Duan, JB ;
Wainwright, MS ;
Comeron, JM ;
Saitou, N ;
Sanders, AR ;
Gelernter, J ;
Gejman, PV .
HUMAN MOLECULAR GENETICS, 2003, 12 (03) :205-216
[2]   The 3′ region of the DRD2 gene is involved in genetic susceptibility to schizophrenia [J].
Dubertret, C ;
Gouya, L ;
Hanoun, N ;
Deybach, JC ;
Adès, J ;
Hamon, M ;
Gorwood, P .
SCHIZOPHRENIA RESEARCH, 2004, 67 (01) :75-85
[3]   VARIABILITY IN D-2-DOPAMINE RECEPTOR DENSITY AND AFFINITY - A PET STUDY WITH [C-11] RACLOPRIDE IN MAN [J].
FARDE, L ;
HALL, H ;
PAULI, S ;
HALLDIN, C .
SYNAPSE, 1995, 20 (03) :200-208
[4]  
HIETALA J, 1994, ARCH GEN PSYCHIAT, V51, P116
[5]  
LAAKSO A, IN PRESS PHARMACOGEN
[6]   D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes [J].
Noble, EP .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 116B (01) :103-125
[7]   The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers [J].
Pohjalainen, T ;
Rinne, JO ;
Nagren, K ;
Lehikoinen, P ;
Anttila, K ;
Syvalahti, EKG ;
Hietala, J .
MOLECULAR PSYCHIATRY, 1998, 3 (03) :256-260