Kruppel-like Factors (KLFs) in muscle biology

被引：97

作者：

Haldar, Saptarsi M.

Ibrahim, Osama A.

Jain, Mukesh K.

机构：

[1] Case Western Reserve Univ, Case Cardiovasc Res Inst, Sch Med, Cleveland, OH 44106 USA

[2] Univ Hosp Cleveland, Div Cardiovasc, Case Med Ctr, Cleveland, OH 44106 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2007年 / 43卷 / 01期

关键词：

KLF; Kruppel; cardiomyocyte; heart; smooth muscle; myocyte; skeletal; transcription;

D O I：

10.1016/j.yjmcc.2007.04.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Kruppel-like Factor (KLF) family of zinc-finger transcription factors are critical regulators of cell differentiation, phenotypic modulation and physiologic function. An emerging body of evidence implicates an important role for these factors in cardiovascular biology, however, the role of KLFs in Muscle biology is only beginning to be understood. This article reviews the published data describing the role of KLFs in the heart, smooth muscle, and skeletal muscle and highlights the importance of these factors in cardiovascular development, physiology and disease pathobiology. (C) 2007 Elsevier Inc. All rights reserved.

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页码：1 / 10

页数：10

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