Glucocorticoids in Alzheimer's disease - The story so far

被引：31

作者：

Aisen, PS ^{[1
]}

Pasinetti, GM ^{[1
]}

机构：

[1] Mt Sinai Med Ctr, Dept Psychiat, New York, NY 10029 USA

来源：

DRUGS & AGING | 1998年 / 12卷 / 01期

关键词：

D O I：

10.2165/00002512-199812010-00001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The inflammatory hypothesis of Alzheimer's disease states that specific inflammatory mechanisms, including the cytokine-driven acute-phase response, complement activation and microglial activation, contribute to neurodegeneration. If the hypothesis is correct, anti-inflammatory treatment aimed at suppression of these mechanisms could slow the rate of disease progression. Towards this goal, a multicentre trial of prednisone in Alzheimer's disease is under way and pilot studies of other anti-inflammatory regimens are being conducted.

引用

页码：1 / 6

页数：6

共 59 条

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