Direct conversion of pyranose anomeric OH→F→R in the artemisinin family of antimalarial trioxanes

被引：42

作者：

Woo, SH

Parker, MH

Ploypradith, P

Northrop, J

Posner, GH ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Arts & Sci, Dept Chem, Baltimore, MD 21218 USA

[2] Res Inst Ind Sci & Technol, Pohang 790600, South Korea

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(98)00132-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Eleven examples form the basis of a short and effective synthetic method for replacement of an anomeric fluorine atom by saturated, unsaturated, aryl and heteroaryl carbon nucleophiles to prepare alpha- or beta-oriented C-10-R derivatives of the trioxane 10-deoxoartemisinin. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1533 / 1536

页数：4

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