Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens

被引：53

作者：

De Naeyer, A

Vanden Berghe, W

Pocock, V

Milligan, S

Haegeman, G

De Keukeleire, D

机构：

[1] Univ Ghent, Lab Pharmacognosy & Phytochem, Fac Pharmaceut Sci, B-9000 Ghent, Belgium

[2] Univ Ghent, Lab Eukaryot Gene Express & Signal Transduct, Fac Sci, Dept Biol Mol, B-9000 Ghent, Belgium

[3] Kings Coll London, Endocrinol & Reprod Res Grp, Sch Biomed Sci, London SE1 1UL, England

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 11期

关键词：

D O I：

10.1021/np040069a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC50 values of 4.6 and 1.66 muM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC50 value = 22.2. muM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay.

引用

页码：1829 / 1832

页数：4

共 53 条

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