Characterization, expression analysis and chromosomal mapping of mouse Matrix Metalloproteinase-19 (MMP-19)

被引：6

作者：

Caterina, JJ ^{[1
]}

Shi, J

Kozak, CA

Engler, JA

Birkedal-Hansen, H

机构：

[1] Natl Inst Dent & Craniofacial Res, Bethesda, MD 20892 USA

[2] NIAID, Bethesda, MD 20892 USA

[3] Univ Alabama, Dept Biochem & Mol Genet, Birmingham, AL USA

来源：

MOLECULAR BIOLOGY REPORTS | 2000年 / 27卷 / 02期

关键词：

arthritis; Mely; MMP-18; RASI-1;

D O I：

10.1023/A:1007196529604

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Using homology-based database screening, we have identified the mouse homologue for the recently described matrix metalloproteinase-19 (MMP-19). Sequencing of mouse MMP-19 resulted in a putative open reading frame (ORF) of 527 amino acids showing 84% identity to the human homologue. In mouse, MMP-19 appears to be most highly expressed in the liver; however, there is a detectable level of expression in all tissues analyzed. The major mouse MMP-19 transcript is almost twice as long as that of human. The COOH-terminal serine and threonine-rich domain is considerably longer in the mouse homologue. The mouse MMP-19 gene maps to very distal end of mouse chromosome 10.

引用

页码：73 / 79

页数：7

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