Genetic linkage of hereditary gingival fibromatosis to chromosome 2p21

被引:78
作者
Hart, TC
Pallos, D
Bowden, DW
Bolyard, J
Pettenati, MJ
Cortelli, JR
机构
[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Pediat, Med Genet Sect, Winston Salem, NC 27157 USA
[2] Wake Forest Univ, Bowman Gray Sch Med, Dept Dent, Winston Salem, NC 27157 USA
[3] Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27157 USA
[4] Univ Taubate, Dept Dent, Sao Paulo, Brazil
关键词
D O I
10.1086/301797
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Gingival fibromatosis is characterized by a slowly progressive benign enlargement of the oral gingival tissues. The condition results in the teeth being partially or totally engulfed by keratinized gingiva, causing aesthetic and functional problems. Both genetic and pharmacologically induced forms of gingival fibromatosis are known. The most common genetic form, hereditary gingival fibromatosis (HGF), is usually transmitted as an autosomal dominant trait, although sporadic cases are common and autosomal recessive inheritance has been reported. The genetic basis of gingival fibromatosis is unknown. We identified an extended family (n = 32) segregating an autosomal dominant form of isolated gingival fibromatosis. Using a genomewide search strategy, we identified genetic linkage (Z(max) = 5.05, theta = .00) for the HGF phenotype to polymorphic markers in the genetic region of chromosome 2p21 bounded by the loci D2S1788 and D2S441. This is the first report of linkage for isolated HGF, and the findings have implications for identification of the underlying genetic basis of gingival fibromatosis.
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页码:876 / 883
页数:8
相关论文
共 24 条
[1]   A gene responsible for a sensorineural nonsyndromic recessive deafness maps to chromosome 2p22-23 [J].
Chaib, H ;
Place, C ;
Salem, N ;
Chardenoux, S ;
Vincent, C ;
Weissenbach, J ;
ElZir, E ;
Loiselet, J ;
Petit, C .
HUMAN MOLECULAR GENETICS, 1996, 5 (01) :155-158
[2]   REPORT OF THE COMMITTEE ON METHODS OF LINKAGE ANALYSIS AND REPORTING [J].
CONNEALLY, PM ;
EDWARDS, JH ;
KIDD, KK ;
LALOUEL, JM ;
MORTON, NE ;
OTT, J ;
WHITE, R .
CYTOGENETICS AND CELL GENETICS, 1985, 40 (1-4) :356-359
[3]  
COTTINGHAM RW, 1993, AM J HUM GENET, V53, P252
[4]   HEREDITARY GENERALIZED GINGIVAL FIBROMATOSIS ASSOCIATED WITH HYPERTRICHOSIS - REPORT OF 5 CASES IN ONE FAMILY [J].
CUESTASCARNERO, R ;
BORNANCINI, CA .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1988, 46 (05) :415-420
[5]   METABOLIC POLYMORPHISMS [J].
DALY, AK ;
CHOLERTON, S ;
GREGORY, W ;
IDLE, JR .
PHARMACOLOGY & THERAPEUTICS, 1993, 57 (2-3) :129-160
[6]   DRUG-INDUCED GINGIVAL OVERGROWTH [J].
DONGARI, A ;
MCDONNELL, HT ;
LANGLAIS, RP .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1993, 76 (04) :543-548
[7]   IDIOPATHIC GINGIVAL FIBROMATOSIS WITH EXTENSIVE OSSEOUS INVOLVEMENT IN A 12-YEAR-OLD BOY - REPORT OF A CASE [J].
FRITZ, ME .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1970, 30 (06) :755-&
[8]  
Fryns JP, 1996, ANN GENET-PARIS, V39, P54
[9]  
GORLIN RJ, 1976, SYNDROMES HEAD NECK, P329
[10]   THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP [J].
GYAPAY, G ;
MORISSETTE, J ;
VIGNAL, A ;
DIB, C ;
FIZAMES, C ;
MILLASSEAU, P ;
MARC, S ;
BERNARDI, G ;
LATHROP, M ;
WEISSENBACH, J .
NATURE GENETICS, 1994, 7 (02) :246-339