Fugu: a compact vertebrate reference genome

被引：113

作者：

Venkatesh, B ^{[1
]}

Gilligan, P ^{[1
]}

Brenner, S ^{[1
]}

机构：

[1] Natl Univ Singapore, Inst Mol & Cell Biol, Singapore 117609, Singapore

来源：

FEBS LETTERS | 2000年 / 476卷 / 1-2期

关键词：

vertebrate genome; Fugu; gene structure; phylogenetic relationship;

D O I：

10.1016/S0014-5793(00)01659-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

At 400 Mb, the Japanese pufferfish, Fugu rubripes, has the smallest vertebrate genome but has a similar gene repertoire to other vertebrates. Its genes are densely packed with short intergenic and intronic sequences devoid of repetitive elements. It likely has a mutational bias towards DNA elimination and is probably close to a 'minimal' vertebrate genome. As such it is a useful reference genome for gene discovery and gene validation in other vertebrates. Its usefulness in the discovery of conserved regulatory elements has already been demonstrated. The Fugu genome sequence is a good complement to genetic studies in other vertebrates. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B,V. All rights reserved.

引用

页码：3 / 7

页数：5

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