Solid-phase synthesis of lipidated peptides

被引：40

作者：

Kragol, G

Lumbierres, M

Palomo, JM

Waldmann, H

机构：

[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany

[2] Univ Dortmund, Fachbereich 3, D-44221 Dortmund, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 43期

关键词：

lipids; proteins; solid-phase synthesis;

D O I：

10.1002/anie.200461150

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Blockers, anchors, and reporters: A solid-phase method for the synthesis of lipidated peptides (see scheme) relies on the base-labile Fmoc group to block the N-terminus, an oxidation-labile hydrazide linker for anchoring to the solid support, and lipidated amino acid building blocks incorporating labels or photoactivatable groups.

引用

页码：5839 / 5842

页数：4

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