How I treat hemochromatosis

被引：135

作者：

Adams, Paul C. ^{[1
]}

Barton, James C. ^{[2
,3
]}

机构：

[1] Univ Western Ontario, Univ Hosp, London, ON N6A 5A5, Canada

[2] So Iron Disorders Ctr, Birmingham, AL USA

[3] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

来源：

BLOOD | 2010年 / 116卷 / 03期

关键词：

INTESTINAL IRON-ABSORPTION; HFE C282Y HOMOZYGOTES; LONG-TERM SURVIVAL; HEREDITARY HEMOCHROMATOSIS; NATURAL-HISTORY; SERUM FERRITIN; GENETIC HEMOCHROMATOSIS; ALCOHOL-CONSUMPTION; PHLEBOTOMY THERAPY; BLOOD-DONATION;

D O I：

10.1182/blood-2010-01-261875

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hemochromatosis is a common genetic disorder in which iron may progressively accumulate in the liver, heart, and other organs. The primary goal of therapy is iron depletion to normalize body iron stores and to prevent or decrease organ dysfunction. The primary therapy to normalize iron stores is phlebotomy. In this opinion article, we discuss the indications for and monitoring of phlebotomy therapy to achieve iron depletion, maintenance therapy, dietary and pharmacologic maneuvers that could reduce iron absorption, and the role of voluntary blood donation. (Blood. 2010; 116(3): 317-325.

引用

页码：317 / 325

页数：9

共 101 条

[1] Haemochromatosis [J].

Adams, Paul C. ;

Barton, James C. .

LANCET, 2007, 370 (9602) :1855-1860

[2] The Natural History of Untreated HFE-Related Hemochromatosis [J].

Adams, Paul C. .

ACTA HAEMATOLOGICA, 2009, 122 (2-3) :134-139

[3] Natural History of Hemochromatosis: Heading Down the Up Escalator? [J].

Adams, Paul C. .

GASTROENTEROLOGY, 2008, 135 (06) :1855-1857

[4] Hemochromatosis and iron-overload screening in a racially diverse population [J].

Adams, PC ;

Reboussin, DM ;

Barton, JC ;

McLaren, CE ;

Eckfeldt, JH ;

McLaren, GD ;

Dawkins, FW ;

Acton, RT ;

Harris, EL ;

Gordeuk, VR ;

Leiendecker-Foster, C ;

Speechley, M ;

Snively, BM ;

Holup, JL ;

Thomson, E ;

Sholinsky, P ;

Acton, RT ;

Barton, JC ;

Dixon, D ;

Rivers, CA ;

Tucker, D ;

Ware, JC ;

McLaren, CE ;

McLaren, GD ;

Anton-Culver, H ;

Baca, JA ;

Bent, TC ;

Brunner, LC ;

Dao, MM ;

Jorgensen, KS ;

Kuniyoshi, J ;

Le, HD ;

Masatsugu, MK ;

Meyskens, FL ;

Morohashi, D ;

Nguyen, HP ;

Panagon, SN ;

Phung, C ;

Raymundo, V ;

Ton, T ;

Walker, AP ;

Wenzel, LB ;

Ziogas, A ;

Adams, PC ;

Bloch, E ;

Chakrabarti, S ;

Fleischhauer, A ;

Harrison, H ;

Jia, K ;

Larson, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (17) :1769-1778

[5] RATE OF IRON REACCUMULATION FOLLOWING IRON DEPLETION IN HEREDITARY HEMOCHROMATOSIS - IMPLICATIONS FOR VENESECTION THERAPY [J].

ADAMS, PC ;

KERTESZ, AE ;

VALBERG, LS .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 1993, 16 (03) :207-210

[6] LONG-TERM SURVIVAL ANALYSIS IN HEREDITARY HEMOCHROMATOSIS [J].

ADAMS, PC ;

SPEECHLEY, M ;

KERTESZ, AE .

GASTROENTEROLOGY, 1991, 101 (02) :368-372

[7]

Adams PC, 1998, AM J HEMATOL, V58, P16, DOI 10.1002/(SICI)1096-8652(199805)58:1<16::AID-AJH3>3.0.CO

[8]

2-3

[9] Diagnosis of liver fibrosis using FibroScan and other noninvasive methods in patients with hemochromatosis:: A prospective study [J].

Adhoute, X. ;

Foucher, J. ;

Laharie, D. ;

Terrebonne, E. ;

Vergniol, J. ;

Castera, L. ;

Lovato, B. ;

Chanteloup, E. ;

Merrouche, W. ;

Couzigou, P. ;

de Ledinghen, V. .

GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, 2008, 32 (02) :180-187

[10] Asymptomatic individuals at genetic risk of haemochromatosis take appropriate steps to prevent disease related to iron overload [J].

Allen, Katrina J. ;

Nisselle, Amy E. ;

Collins, Veronica R. ;

Williamson, Robert ;

Delatycki, Martin B. .

LIVER INTERNATIONAL, 2008, 28 (03) :363-369

← 1 2 3 4 5 6 7 8 9 10 →