Accumulating evidence demonstrates that adult tissues contain a population of stem cells that express early developmental markers such as stage-specific embryonic antigen and transcription factors Oct-4 and Nanog. These are the markers characteristic for embryonic stem cells, epiblast stem cells and primordial germ cells. The presence of these stem cells in adult tissues including bone marrow, epidermis, bronchial epithelium, myocardium, pancreas and testes supports the concept that adult tissues contain some population of pluripotent stem cells that is deposited in embryogenesis during early gastrulation. In this review we will discuss these data and present a hypothesis that these cells could be direct descendants of the germ lineage. The germ lineage in order to pass genes on to the next generations creates soma and thus becomes a 'mother lineage' for all somatic cell lineages present in the adult body.
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Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Andrews, PW
Matin, MM
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机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Matin, MM
Bahrami, AR
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机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Bahrami, AR
Damjanov, I
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机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Damjanov, I
Gokhale, P
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机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Gokhale, P
Draper, JS
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机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
机构:
London Res Inst, Canc Res UK, Haematopoiet Stem Cell Lab, London WC2A 3PX, EnglandLondon Res Inst, Canc Res UK, Haematopoiet Stem Cell Lab, London WC2A 3PX, England
Anjos-Afonso, Fernando
Bonnet, Dominique
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London Res Inst, Canc Res UK, Haematopoiet Stem Cell Lab, London WC2A 3PX, EnglandLondon Res Inst, Canc Res UK, Haematopoiet Stem Cell Lab, London WC2A 3PX, England
机构:
Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Andrews, PW
Matin, MM
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h-index: 0
机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Matin, MM
Bahrami, AR
论文数: 0引用数: 0
h-index: 0
机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Bahrami, AR
Damjanov, I
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h-index: 0
机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Damjanov, I
Gokhale, P
论文数: 0引用数: 0
h-index: 0
机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Gokhale, P
Draper, JS
论文数: 0引用数: 0
h-index: 0
机构:Univ Sheffield, Western Bank, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
机构:
London Res Inst, Canc Res UK, Haematopoiet Stem Cell Lab, London WC2A 3PX, EnglandLondon Res Inst, Canc Res UK, Haematopoiet Stem Cell Lab, London WC2A 3PX, England
Anjos-Afonso, Fernando
Bonnet, Dominique
论文数: 0引用数: 0
h-index: 0
机构:
London Res Inst, Canc Res UK, Haematopoiet Stem Cell Lab, London WC2A 3PX, EnglandLondon Res Inst, Canc Res UK, Haematopoiet Stem Cell Lab, London WC2A 3PX, England