6-Hz primed low-frequency rTMS to contralesional M1 in two cases with middle cerebral artery stroke

被引：19

作者：

Carey, James R. ^{[1
]}

Anderson, David C. ^{[2
]}

Gillick, Bernadette T. ^{[3
]}

Whitford, Maureen ^{[3
]}

Pascual-Leone, Alvaro ^{[4
,5
,6
]}

机构：

[1] Univ Minnesota, Program Phys Therapy, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Grad Program Rehabil Sci, Minneapolis, MN 55455 USA

[4] Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

[6] Univ Autonoma Barcelona, Inst Gutmann Neurorehabil, E-08193 Barcelona, Spain

来源：

NEUROSCIENCE LETTERS | 2010年 / 469卷 / 03期

关键词：

fMRI; rTMS; Stroke; Hand; TRANSCRANIAL MAGNETIC STIMULATION; PRIMARY MOTOR CORTEX; INTERHEMISPHERIC INHIBITION; HOMEOSTATIC PLASTICITY; CORTICAL PLASTICITY; HEMIPARETIC STROKE; CONTROLLED TRIAL; FINGER TRACKING; HAND FUNCTION; REORGANIZATION;

D O I：

10.1016/j.neulet.2009.12.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

This case study contrasted two subjects with stroke who received 6-Hz primed low-frequency repetitive transcranial magnetic stimulation (rTMS) to the contralesional primary motor area (M1) to disinhibit ipsilesional M1. Functional magnetic resonance imaging (fMRI) showed that the intervention disrupted cortical activation at contralesional M1. Subject 1 showed decreased intracortical inhibition and increased intracortical facilitation following intervention during paired-pulse TMS testing of ipsilesional M1. Subject 2, whose precentral knob was totally obliterated and who did not show an ipsilesional motor evoked potential at pretest, still did not show any at posttest; however, her fMRI did show a large increase in peri-infarct zone cortical activation. Behavioral results were mixed, indicating the need for accompanying behavioral training to capitalize on the brain organization changes induced with rTMS. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：338 / 342

页数：5

共 37 条

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