Intrastriatal Transplantation of GDNF-engineered BMSCs and its neuroprotection in Lactacystin-induced Parkinsonian Rat Model

被引：33

作者：

Wu, Jianjun ^{[1
]}

Yu, Wenbo ^{[1
]}

Chen, Yan ^{[1
]}

Su, Yaru ^{[1
]}

Ding, Zhengtong ^{[1
]}

Ren, Huimin ^{[1
]}

Jiang, Yuping ^{[1
]}

Wang, Jian ^{[1
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai 200040, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2010年 / 35卷 / 03期

基金：

上海市自然科学基金;

关键词：

Parkinson's disease; Glial cell line-derived neurotrophic factor; Lentivirus; Gene therapy; Bone marrow stromal cells; Lactacystin; MARROW STROMAL CELLS; RETRACTED ARTICLE. SEE; ALPHA-SYNUCLEIN; NEUROTROPHIC FACTOR; DISEASE; IMPAIRMENT; PATHOLOGY; DELIVERY; FORM;

D O I：

10.1007/s11064-009-0086-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The potential value of glial cell line-derived neurotrophic factor (GDNF) in treating Parkinson's disease (PD) remains controversial. In order to evaluate the therapeutic effect of GDNF-engineered bone marrow stromal cells (BMSCs) in parkinsonian rat model, GDNF-BMSCs and LacZ-BMSCs were transplanted into striatum and followed by Lactacystin lesioning at median forebrain bundles 1 week later. We observed that the intrastriatal transplantation of GDNF-BMSCs could significantly rescue the dopaminergic neurons from lactacystin-induced neurotoxicity with regard to behavioral recovery, tyrosine hydroxylase level in nigra and striatum, and striatal dopamine level. We interpret the outcomes that intrastriatal transplantation of GDNF-BMSCs might be beneficial in the treatment of PD.

引用

页码：495 / 502

页数：8

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